To be fed up or sick of something; to find something tedious or tiresome (used like 'to be fed up with ~').
毎日の残業にうんざりして、転職を考え始めた。
I'm fed up with working overtime every day and have started thinking about changing jobs.
彼の同じ冗談にはもううんざりだ。
I'm already tired of his same jokes.
何度も失敗してうんざりしたが、諦めずに続けた。
I was fed up after failing many times, but I kept going without giving up.