A polite/respectful form of 仕事 (work, job, task). Used to ask about or refer to someone's occupation or tasks politely.
失礼ですが、お仕事は何をされていますか？
Excuse me, but what do you do for work?
明日は急なお仕事が入ったため、早く帰れません。
Because an urgent job came up tomorrow, I can't go home early.
お仕事お疲れさまでした。ゆっくり休んでください。
Thank you for your work. Please rest well.
子どもはお父さんに『お仕事に行ってきます』と言って家を出た。
The child said to his father, 'I'm going to work,' and left the house.