A common polite greeting meaning 'How are you?' used to ask about someone's health or condition.
久しぶり！お元気ですか？
Long time no see! How are you?
電話で話すとき、最初に『お元気ですか』と尋ねるのが普通だ。
When talking on the phone, it's common to start by asking 'How are you?'
年配の方に会ったら、まずお元気ですかと声をかけると喜ばれることが多い。
If you meet an elderly person, they are often pleased if you first ask 'How are you?'