Being at one’s wits' end; helplessness; giving up or being in a hopeless situation.
この問題は複雑で私にはもうお手上げだ。
This problem is complicated; I'm completely stumped.
サポートセンターも調べたが結局お手上げになった。
I checked with the support center, but in the end they gave up.
山道で方向を見失い、私たちはお手上げの状態だった。
We lost our way on the mountain trail and were at our wits' end.