itself — used to emphasize the thing in question (referring to the object or matter itself)
問題それ自身は小さいが、連鎖反応が怖い。
The problem itself is small, but the chain reaction is worrying.
その機械それ自身は故障していなかった。
The machine itself was not broken.
それ自身で解決できることも多い。
There are many things that can be solved by themselves / on their own.