intolerable; unbearable; something one cannot endure (used to express strong discomfort or distress)
二日間寝ていなくて頭が痛くてたまらない。
I haven't slept for two days and my head is unbearably painful.
寒くてたまらないのでコートを着た。
It was so cold I couldn't stand it, so I put on a coat.
あの音がうるさくてたまらない。
That noise is unbearably loud.
irresistible; tremendous; extremely appealing or overwhelming in a positive way
赤ちゃんがかわいくてたまらない。
The baby is irresistibly cute.
新作の味が最高でたまらない。
The new dish tastes so good—it's irresistible.
彼の演奏は素晴らしくてたまらない。
His performance is so wonderful it's overwhelming.
cannot help (doing); feel an urgent desire or need to do something; cannot get enough of — often follows the -te form
会いたくてたまらないので、明日会いに行くつもりだ。
I can't help wanting to see you, so I plan to visit tomorrow.
眠くてたまらないから、今日は早く寝る。
I'm unbearably sleepy, so I'll go to bed early today.
その映画が見たくてたまらない。
I can't wait to see that movie.