An expression meaning something cannot be helped or there is nothing one can do; conveys hopelessness or that a situation is beyond remedy.
この状況はどうしようもないから、まずは被害を最小限に抑えよう。
Since this situation can't be helped, let's first try to minimize the damage.
彼のわがままにはもうどうしようもない。
There's nothing we can do about his selfishness anymore.
病気のときは、自分の体調に任せるしかなくて、どうしようもない気持ちになることがある。
When you're ill, you sometimes feel helpless because you just have to leave it to your body's recovery.