An adverb meaning 'anyhow' or 'in any case', often expressing resignation or dismissiveness (e.g., 'it's no use; anyway').
どうせ無理だから最初からやらなかった。
I didn't do it from the start because I thought it was impossible anyway.
どうせ来ないだろうと思っていた。
I thought he wouldn't come anyway.
どうせなら最後まで頑張ろう。
If that's the case anyway, let's try our best until the end.
An adverb meaning 'at best' or 'at most', used to express a low estimate or limited expectation.
どうせ100円くらいしか変わらないよ。
It won't change by more than about 100 yen anyway.
彼が来たとしても、どうせすぐ帰るだろう。
Even if he comes, he'll probably leave soon at best.
その問題を直しても、どうせ意味がない。
Even if we fix that problem, it's pointless anyway.