(Used with negatives) in no way; not at all; no matter what — expresses that nothing can be done or that something is hopeless.
彼の気持ちはどうにも変えられない。
His feelings can't be changed no matter what.
雨で試合はどうにもならなかった。
Because of the rain, the match was beyond saving.
説明してもどうにも理解してくれない。
Even if I explain, they just can't understand.
Used adverbially to mean 'terribly', 'awfully', or 'hopelessly' (indicating a strong degree).
今日はどうにも眠くて仕事が手につかない。
I'm terribly sleepy today and can't concentrate on my work.
その話を聞いてどうにも心が痛んだ。
Hearing that story made me feel deeply pained.