An emphatic expression meaning 'in no way' or 'no matter what one does' — conveys that something cannot be done or resolved at all.
どうにもこうにも時間が足りないので、計画を変えざるを得ない。
No matter what, there isn't enough time, so we have to change the plan.
その問題はどうにもこうにも手に負えない。
That problem is beyond help; there's nothing we can do about it.
彼の態度はどうにもこうにも受け入れがたい。
His attitude is completely unacceptable (no matter what).