Despite; in spite of; used to indicate that something happens contrary to an existing fact or situation (similar to 'although').
雨にもかかわらず、運動会は予定どおり行われた。
Despite the rain, the sports day was held as scheduled.
経験が浅いにもかかわらず、彼はよくやった。
Although he has little experience, he did well.
値段が高いにもかかわらず、商品はよく売れている。
Despite the high price, the product is selling well.
Nonetheless; nevertheless; used as a conjunction to show contrast, often placed at the start or middle of a sentence.
資料は十分に準備していた。にもかかわらず、会議は遅れて始まった。
The materials were well prepared. Nevertheless, the meeting started late.
リスクが高いにもかかわらず、彼らは投資を続けた。
Despite the high risks, they continued to invest.
忙しいにもかかわらず、彼は手伝ってくれた。
Even though he was busy, he helped me.