An interjection used to tell someone to stop something or to express disbelief/annoyance ("Stop it!" or "Cut it out!").
やめろと言ったのに、まだからかうのか。よせ！
I told you to stop, but are you still teasing me? Cut it out!
冗談はよせよ。本当のことを言ってくれ。
Come on, enough joking. Tell me the truth.
そんなひどい話を聞かせるな。よせ、もうやめてくれ。
Don't tell me such awful stories. Stop it — please stop.
痛いから、そんなことするのはよせ！
It hurts, so stop doing that!