Used to say one cannot do something due to external circumstances, obligations, or common sense; implies you must not or cannot afford to do it.
みんなが頼っているから、逃げるわけにはいかない。
Everyone is relying on me, so I can't run away.
この問題は重要だから、簡単に諦めるわけにはいかない。
This issue is important, so I can't give up easily.
社内ルールなので、個人的に許可するわけにはいかない。
Because it's a company rule, I can't personally allow it.