An idiomatic, colloquial expression meaning to get very angry; stronger than 'atama ni kuru' (to get angry). Somewhat dated.
彼の無礼な言い方にとさかに来て、言い返した。
I got furious at his rude remark and answered back.
上司に責任を押しつけられたときは、本当にとさかに来るよ。
When the boss pins responsibility on you, it really makes you furious.
そんな冗談を何度も言われると、とさかに来るんだからね。
If you keep telling that joke, I'll get really mad, you know.