Originally from Chinese medicine: the five viscera and six entrails — referring to the internal organs as a whole.
古典医学では五臓六腑のバランスが健康に関係すると考えられている。
In classical medicine, the balance of the five viscera and six entrails is thought to relate to health.
漢方では五臓六腑の状態を診て処方を決める。
In Kampo (Chinese herbal medicine), prescriptions are decided after assessing the state of the five viscera and six entrails.
五臓六腑に染み渡るような温かいスープを飲んだ。
I drank a warm soup that seemed to soak into my whole body (deeply warming).
Figuratively, the inside of one's body or the depths of one's heart — used to emphasize deep internal feeling or sensation.
あの知らせは彼の五臓六腑に響いた。
That news struck him to his very core.
祖母の作る味噌汁はいつも五臓六腑に染み渡る味だ。
My grandmother's miso soup always has a flavor that warms me through and through.
彼女の歌声は聴く人の五臓六腑に訴えかける。
Her singing appeals to the listener's deepest feelings.