An expression meaning 'in any case' or 'anyhow'; used to state a conclusion or to change the direction of a discussion. Colloquially pronounced 'nan ni shiro'.
何にしろ、まずは体を休めることが大事だ。
In any case, the important thing is to rest your body first.
彼の意見には賛成できないが、何にしろ早く結論を出そう。
I can't agree with his opinion, but anyway let's reach a conclusion quickly.
時間が足りないなら、何にしろ最も重要な部分から手をつけて。
If time is short, in any case start with the most important parts.