An expression meaning 'before anything else' or 'first of all', used to set other matters aside and emphasize the primary thing.
何はさておき、まず自己紹介をお願いします。
Before anything else, please introduce yourself.
試験中は何はさておき集中することが大事だ。
During exams, concentrating is important above all else.
何はさておき、夕飯にしよう。
Putting everything else aside, let's have dinner first.