beyond recovery or unable to be revived/returned to a former state; irrecoverable (applies to machines, people, reputations, etc.).
事故でエンジンは再起不能となり、交換が必要になった。
The engine was rendered irrecoverable in the accident and had to be replaced.
あのスキャンダルで彼の政治生命は事実上再起不能だと言われている。
Because of that scandal, people say his political career is essentially beyond recovery.