By all possible means; trying many different approaches or variations repeatedly to achieve something.
彼は手を変え品を変え、友達を自分のイベントに誘おうとした。
He tried every trick in the book, using different approaches to invite his friends to the event.
店は手を変え品を変え、新商品を次々と出して顧客を引きつけている。
The shop keeps changing things up—introducing new products one after another—to attract customers.
手を変え品を変え説得したが、結局彼女の意志は変わらなかった。
I tried every way I could to persuade her, but in the end her decision didn't change.