Care or maintenance — tending, grooming, repairing, or otherwise taking care of something to keep it in good condition.
車は定期的に手入れをしておかないと故障しやすい。
If you don't maintain your car regularly, it's more likely to break down.
庭の手入れをして花壇をきれいにした。
I tended the garden and made the flower beds look nice.
古い家具の手入れには専用のクリームを使うとよい。
It's good to use a special cream to care for old furniture.
A police raid or crackdown — e.g., a search or sudden inspection carried out by authorities (often used as 'a raid is carried out').
違法営業の疑いがあり、昨夜この店に手入れが入った。
Authorities raided the shop last night on suspicion of illegal operations.
その会社には税務署の手入れが入ったと聞いた。
I heard the tax office conducted a raid/inspection at that company.