severe; painful — describing a considerable or damaging loss/blow
彼は大事な契約を失い、手痛い代償を払った。
He lost an important contract and paid a heavy price.
その敗北はチームにとって手痛い打撃だった。
That defeat was a painful blow for the team.
手痛い経験から多くを学んだ。
He learned a lot from that painful experience.