The least; the lowest or minimum in terms of amount or degree.
この作業には最低でも三人必要だ。
This task requires at least three people.
追加入金は最低一万円から受け付けます。
Additional deposits are accepted from a minimum of 10,000 yen.
Worst; used to condemn someone's behavior or character strongly (colloquial).
彼の裏切りは本当に最低だと思う。
I really think his betrayal is the lowest/most despicable.
そんな嘘をつくなんて最低だよ。
That's awful—telling such a lie.
彼女の無責任な発言は最低と言わざるをえない。
I have to say her irresponsible remarks are the worst.
Awful, disgusting, or nasty; giving a very negative impression.
彼の部屋は最低に汚かった。
His room was disgustingly filthy.
その料理は味も見た目も最低だった。
That dish was awful in both taste and appearance.
As an adverb meaning 'at the very least' or 'at minimum' (colloquial usage, e.g., 'at least').
最低でも明日の朝までに返事をください。
Please reply by at least tomorrow morning.
最低、約束は守ってほしい。
At minimum, I want you to keep your promise.