To become tired from walking; to be exhausted due to walking for a long time.
駅から家まで歩き疲れて、ソファに倒れ込んだ。
I was so tired from walking from the station to my house that I collapsed onto the sofa.
子どもたちは遠足で歩き疲れて、昼寝をしてしまった。
The children were worn out from walking on the excursion and took a nap.
歩き疲れたら、無理をせず休憩を取ってください。
If you get tired from walking, please rest without pushing yourself.