Total annihilation or extermination; to wipe out completely. Often used in military contexts or metaphorically (commonly appears as 殲滅する).
司令官は敵の部隊を殲滅するよう命じた。
The commander ordered the annihilation of the enemy unit.
害虫駆除のために徹底的な殲滅作戦が行われた。
A thorough extermination campaign was carried out to eliminate the pests.
そのチームは今季、ライバルを殲滅するほど圧勝した（比喩）。
That team crushed their rivals so thoroughly this season it was as if they annihilated them (figurative).