To become tired or fatigued; to grow weary (intransitive).
長時間歩いて足が疲れた。
I walked for a long time and my legs got tired.
仕事が忙しくて精神的に疲れている。
I'm mentally tired because work has been busy.
今日はあまり動いていないのにやけに疲れる。
I'm unusually tired today even though I haven't moved much.
授業の後はいつも疲れて眠くなる。
After class I'm always tired and get sleepy.
To become worn out (of a frequently used object); to lose condition or function through use.
この靴はもう何年も履いていて、だいぶ疲れてきた。
I've been wearing these shoes for years and they've become quite worn out.
古い機械は疲れて効率が落ちている。
The old machine is worn out and its efficiency has dropped.
An archaic meaning: to starve (obsolete usage). Rarely used in modern Japanese.
（文語・古語の例）飢え疲れて道端に倒れた、という表現が古い文献に見られる。
(Classical/archaic example) Expressions like 'collapsed by starvation' can be seen in old texts.