To look down on/from above; to have a view overlooking something (to command a view of).
山頂から町を見下ろすと、小さな家々が点々として見えた。
Looking down at the town from the mountaintop, small houses appeared scattered below.
ホテルの部屋の窓から庭を見下ろせる。
You can look down at the garden from the hotel room window.
高層ビルが街路を見下ろしている。
The skyscraper overlooks the street below.
To look down on someone; to despise or hold someone in contempt.
彼はいつも部下を見下ろすような態度で話す。
He always speaks to his subordinates in a condescending way.
人を見下ろすのはやめたほうがいい。
You should stop looking down on people.
そんなに見下ろすように言わないでください。
Please don't speak to me so condescendingly.