To defeat; to beat an opponent (transitive).
彼は大会で強敵を負かして優勝した。
He defeated a strong opponent at the tournament and won.
あのチームは簡単には負かせない。
That team can't be beaten easily.
監督は選手たちに相手の弱点を突いて負かすよう指示した。
The coach instructed the players to exploit the opponent's weaknesses and defeat them.