To accept blame or assume responsibility for a fault or failure; to bear the burden of blame or liability.
プロジェクトの失敗について責めを負うのは難しいが、まず原因を調べるべきだ。
It's hard to take the blame for the project's failure, but we should first investigate the cause.
部長が責めを負って辞任した。
The manager took the blame and resigned.
彼は誤診による損害について責めを負う立場にある。
He is in a position to bear responsibility for the damage due to the misdiagnosis.