In a responsible manner; with a sense of responsibility — doing something properly and seeing it through.
この仕事は最後まで責任を持ってやってください。
Please take responsibility for this job until the end.
親は子供の安全に責任を持って行動するべきだ。
Parents should act responsibly for their children's safety.
契約内容をよく確認し、責任を持って署名してください。
Please carefully check the contract terms and sign with responsibility.