To drink oneself into a stupor; to get so drunk that one passes out or becomes incapacitated.
彼は二軒目で飲みつぶれて家に帰れなくなった。
He got plastered at the second bar and couldn't get home.
夜遅く公園で飲みつぶれている人を見かけたので、救急車を呼んだ。
I saw someone passed out drunk in the park late at night and called an ambulance.
飲みすぎて飲みつぶれるのは体にも良くない。
Drinking so much that you pass out is also bad for your health.