Top leaders or heads of an organization or state; those at the highest leadership level (as in summits).
首脳会談は来週東京で行われる。
The summit will be held in Tokyo next week.
各国の首脳が集まって経済問題を議論した。
Heads of state gathered to discuss economic issues.
首脳陣は声明を発表した。
The leadership issued a statement.
An archaic sense meaning an important core or central figure (often written 主脳).
古い記録では『主脳』が組織の重要な中心を指している。
In old records, '主脳' refers to the important core of an organization.