To settle in a place for the rest of one's life; to make a place one's final home.
彼は都会の喧騒を嫌い、田舎で骨を埋める決心をした。
He disliked the city's noise and decided to make the countryside his final home.
この町で骨を埋めたいと言って、家を建て始めた。
He said he wanted to spend the rest of his life in this town and began building a house.
戦後、故郷で骨を埋めた人が多い。
After the war, many people settled and spent the rest of their lives in their hometowns.
To devote the rest of one's life to something; to spend one’s life working in a particular field or on a particular cause.
彼女は医療に骨を埋める覚悟で、大学院で研究を続けている。
She is continuing graduate research, determined to devote her life to medicine.
画家として骨を埋めるつもりで、この町にアトリエを構えた。
He set up a studio in this town with the intention of devoting his life to being a painter.
一つの分野に骨を埋める覚悟がないと、長続きはしない。
If you don't have the resolve to devote yourself to one field, you won't last long.