To feel weary or worn out; to be physically exhausted (mimetic/onomatopoeic).
長時間の立ち仕事で足が痛くなり、げんなりした。
After standing for a long time my feet hurt and I felt worn out.
徹夜続きで彼はげんなりした顔をしていた。
After nights without sleep he looked completely drained.
To be fed up or sick of something; to feel disgusted or exasperated after repetition or annoyance.
彼の自慢話が続いて、みんなげんなりしていた。
His boasting went on and everyone grew fed up.
同じミスを何度も指摘されて、げんなりした。
Being told about the same mistake repeatedly made me fed up.
To feel dejected or disheartened; to be downcast after disappointment.
試験に落ちて、彼女はげんなりと肩を落とした。
She slumped dejectedly after failing the exam.
期待していた発表が中止になり、みんなげんなりした表情だった。
The presentation we were looking forward to was canceled, and everyone looked dispirited.