To be fed up with something; to have had enough (of); unwilling to go through it again.
もう彼の遅刻にはこりごりだ。
I'm fed up with his being late.
同じトラブルが続いて、社員はその仕事にこりごりしている。
After repeated problems, the staff are fed up with that job.
彼の自慢話にはもうこりごりだ。
I'm sick and tired of his boasting.
To learn one's lesson from a bad experience; to be reluctant to repeat the same mistake.
あの嫌な目に遭って、もう同じ投資はしないとこりごりした。
After that unpleasant experience, I learned my lesson and won't make the same investment again.
子供は転んで泣いたが、痛さを知ってこりごりしたようだ。
The child fell and cried, but having felt the pain seemed to learn their lesson.