Off the mark; misguided or irrelevant — an opinion or judgment that misses the point or is inaccurate.
その指摘は的外れで、問題の本質を理解していない。
That remark is off the mark and doesn't understand the essence of the problem.
彼の意見は質問の趣旨から的外れだった。
His opinion was off-topic relative to the intent of the question.
その推測はかなり的外れで、証拠が欠けている。
That speculation is quite off the mark and lacks evidence.